Inhibition of rat dihydropyrimidine dehydrogenase by 5-cyanouracil in vitro.
نویسندگان
چکیده
منابع مشابه
Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase.
The kinetic properties and control mechanisms of 5-fluorouracil (5-FU), uracil, and thymine degradation by rat liver dihydropyrimidine dehydrogenase were studied in vitro. The calculated Michaelis constant (Km) for 5-FU was 3.49 +/- 0.41 (SE) microM, similar to those for uracil (2.26 +/- 0.28 microM) and for thymine (2.23 +/- 0.34 microM). However, the reduction of 5-FU appears to be most sensi...
متن کاملIn vivo inhibition of pyrimidine catabolism by 5-cyanouracil.
SUMMARY The peak in vivo rates of catabolism to ‘‘@ CO2 of 4 C and of @ C were delayed from 30 to 90 mm in rats when excess thymine or excess 5-cyanouracil were injected together with the labeled compound. The delay was greater with 5-cyanouradil, which is a known inhibitor of rat liver pyrimidine reductase. When the peak output of 1 4 CO2 was thus delayed , the total recovery of @ @ C decr...
متن کاملEffect of vitamin B2 deficiency on rat liver dihydropyrimidine dehydrogenase activity.
Effect of vitamin B2 deficiency on rat liver dihydropyrimidine dehydrogenase was investigated. It was found that the purified enzyme contains 2 mol flavin per molecule, which consists of equal proportions of flavin-adenine dinucleotide (FAD) and riboflavin 5'-phosphate (FMN). When rats were fed on a vitamin B2-deficient diet for 5 weeks, dihydropyrimidine dehydrogenase activity in the liver was...
متن کاملVARIATIONS BY EPINEPHRINE OF HEPATIC AND SERUM AMINOTRANSFERASES AND LACTATE DEHYDROGENASE IN THE RAT
Incubation of rat hepatocytes with epinephrine inhibited alanine aminotransferase (ALT) (80%) and aspartate aminotransferase (AST) (53%) activities with no effect on lactate dehydrogenase (LDH) activity. Injection of epinephrine caused a progressive increase with time in hepatic LDH activity, being 52% at 24 h. Preinjection with propranolol eliminated the hormone effect and caused further ...
متن کامل5-FU multifocal inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency
inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency Article abstract—Multifocal inflammatory leukoencephalopathy (MIL) is a cerebral demyelinating syndrome that develops after chemotherapy with 5-fluorouracil (5-FU) and levamisole. The authors report a patient who developed MIL after 5-FU administration not in association with levamisole. She was subsequently diagnos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer research
دوره 29 1 شماره
صفحات -
تاریخ انتشار 1969